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Ethoxidol® is an original medicine for the treatment of cerebrovascular disorders with a novel antioxidant mechanism

Ethoxidol® helps cell survive, reduces the harmful effects of ischemia (lack of blood supply) and helps to restore neurological and mental activity.

Indications for the medication:

  • ischemic heart disease (as part of integrated therapy);
  • complex therapy of ischemic stroke;
  • dissociative encephalopathy;
  • mild to moderate cognitive disorders.

Key advantages:

  • restores the cell's own antioxidant – glutathione1-2;
  • gives 2.5 times more energy (ATP*) to cells during ischemia1-2, 6-11;
  • better penetrates the blood-brain barrier3-5;
  • has an antihypoxic effect3,4,6,14;
  • improves the rheological properties of blood3,4,6,14;
  • has a hypolipidemic effect3,4,6,14;
  • does not cause cell death in ischemia and hypoxia7,11;
  • allows to compensate for malate deficiency in ischemia7,12,13.

* ATP - adenosine triphosphate.

1 Katsunori Shijo. Metabolic fate of glucose in rats with traumatic brain injury and pyruvate or glucose treatments: A NMR spectroscopy study. Neurochem Int. 2017 Jan; 102: 66–78.

2 Cerdán S. Twenty-seven Years of Cerebral Pyruvate Recycling. Neurochem Res. 2017 Jun;42(6):1621-1628.

3 Instruction for medical use of Etoxidol® solution for intravenous and intramuscular administration.

4 Instruction for medical use of Etoxidol® chewable tablets.

5 Amber Dahlin. Expression Profiling of the Solute Carrier Gene Family in the Mouse Brain. The Journal of Pharmacology and Experimental Therapeutics. 2009.

6 Dadasheva M.N., Taranenko N.Yu., et al. Pathogenetic therapy with a new domestic antioxidant Ethoxidol in cerebrovascular disease. Family Medicine Bulletin No. 1–2 - 2015.

7 Chinopoulos C. Which way does the citric acid cycle turn during hypoxia? The critical role of α-ketoglutarate dehydrogenase complex. J Neurosci Res. 2013 Aug;91(8):1030-43.

8 Pyruvate recycling in cultured neurons from cerebellum. J Neurosci Res. 2007 Nov 15;85(15):3318-25.

9 Bricker DK. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science, 2012.

10 Metabolic fate of glucose in rats with traumatic brain injury and pyruvate or glucose treatments: A NMR spectroscopy study. Neurochem Int. 2017 Jan; 102: 66–78.

11 Preservation of complex I function during hypoxia-reoxygenation-induced mitochondrial injury in proximal tubules. Am J Physiol Renal Physiol 286: F749–F759, 2004.

12 L-Malate's Plasma and Excretion Profile in the Treatment of Moderate and Severe Hemorrhagic Shock in Rats 2016.

13 Intravascular volume therapy in adults Guidelines from the Association of the Scientific Medical Societies in Germany 2016.

14 L.N. Sernov et al. Results of a study of a domestic medicine, an antioxidant of the second generation - ethoxidol. Ed. and with the participation of: acad. RAS, prof. Archakova A.I., acad. RAS, Hon. scientist, prof. d.m.s. Kukesa V.G., Assoc. Dmitrieva D.A. ANO International Association of Clinical Pharmacologists and Pharmacists. 2014.